Protective effects of intra-articular formulated liraglutide in osteoarthritis : preclinical studies

Intra-articular therapy in osteoarthritis.

The medical literature was reviewed from 1968-2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy,...

Intra-articular corticosteroid injections in osteoarthritis: do

Intra-articular (IA) corticosteroids are recommended in several guidelines for the treatment of patients with knee osteoarthritis (OA). 2 They are also widely used: a recent survey of rheumatologists in the United States suggesting that over 95% use them at least ‘sometimes’ and 53% ‘frequently’. Before considering mechanisms of action of IA corticsteroids we should first consider the evidence ...

Intra-articular corticosteroid injections in osteoarthritis: do

Intra-articular (IA) corticosteroids are recommended in several guidelines for the treatment of patients with knee osteoarthritis (OA). 2 They are also widely used: a recent survey of rheumatologists in the United States suggesting that over 95% use them at least ‘sometimes’ and 53% ‘frequently’. Before considering mechanisms of action of IA corticsteroids we should first consider the evidence ...

Effects of intra-articular hyaluronic acid and corticosteroid therapies on articular cartilage in experimental severe osteoarthritis.

Intra-articular corticosteroid injection for osteoarthritis

Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...